4-Aminopiperidine derivatives as a new class
of potent cognition enhancing drugs

Manetti D, Martini E, Ghelardini C, Dei S, Galeotti N,
Guandalini L, Romanelli MN, Scapecchi S,
Teodori E, Bartolini A, Gualtieri F.
Dipartimento di Scienze Farmaceutiche,
Universita di Firenze,
Via G. Capponi 9, I-50121, Firenze, Italy.
Bioorg Med Chem Lett. 2003 Jul 21;13(14):2303-6


Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.

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