Antioxidant-rich diets improve cerebellar physiology
and motor learning in aged rats

Bickford PC, Gould T, Briederick L, Chadman K,
Pollock A, Young D, Shukitt-Hale B, Joseph J.
Department of Pharmacology,
Boston, MA, USA.
Brain Res 2000 Jun 2;866(1-2):211-71


The free radical theory of aging predicts that reactive oxygen species are involved in the decline in function associated with aging. The present paper reports that diets supplemented with either spinach, strawberries or blueberries, nutritional sources of antioxidants, reverse age-induced declines in beta-adrenergic receptor function in cerebellar Purkinje neurons measured using electrophysiological techniques. In addition the spinach diet improved learning on a runway motor task, previously shown to be modulated by cerebellar norepinephrine. Motor learning is important for adaptation to changes in the environment and is thus critical for rehabilitation following stroke, spinal cord injury, and the onset of some neurodegenerative diseases. These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions.

New brain cells
The memory switch?
Dumb-drug euphoria
Growing new brain cells
Blueberries and memory
Do blueberry polyphenols increase lifespan?
Do polyphenol-rich blueberries protect eyesight?
Blueberry-induced changes in spatial working memory
Polyphenol-rich wild blueberry extract and cognitive performance
Impact of berry fruits on human health, performance, and disease

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family