Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
by
Joseph JA, Shukitt-Hale B, Denisova NA,
Bielinski D, Martin A, McEwen JJ, Bickford PC.
United States Department of Agriculture,
Human Nutrition Research Center on Aging,
Tufts University, Boston, Massachusetts 02111, USA.
J Neurosci 1999 Sep 15;19(18):8114-21


ABSTRACT

Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

Brainfood
Apple juice
Blueberries
Slimming food?
New brain cells
Antioxidant diets
The memory switch?
Dumb-drug euphoria
Growing new brain cells
Do blueberry polyphenols increase lifespan?
Do polyphenol-rich blueberries protect eyesight?
Blueberry-induced changes in spatial working memory
Polyphenol-rich wild blueberry extract and cognitive performance
Impact of berry fruits on human health, performance, and disease




Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family