Caffeine reversal of ethanol effects on the multiple sleep latency test, memory, and psychomotor performance
Drake CL, Roehrs T, Turner L, Scofield HM, Roth T.
Sleep Disorder and Reserch Center,
Henry Ford Hospital, Detroit, MI 48202, USA.
Neuropsychopharmacology. 2003 Feb;28(2):371-8. Epub 2002 Jul 15
ABSTRACTCaffeine has been shown to reverse some of the performance-impairing effects of ethanol. However, it is not known whether this antagonistic effect of caffeine is mediated by a reduction in sleepiness. The present study assessed physiological alertness/sleepiness, memory, and psychomotor performance following the administration of placebo, ethanol, and caffeine+ethanol combinations. A total of 13 healthy individuals (21-35 years old) underwent four conditions presented in a Latin Square Design: placebo-placebo, ethanol (0.5 g/kg)-placebo, ethanol (0.5 g/kg)-caffeine 150 mg, and ethanol (0.5 g/kg)-caffeine 300-mg. The Multiple Sleep Latency Test (MSLT), psychomotor performance battery, memory test, and mood/sleepiness questionnaires were administered following each condition. The peak breadth ethanol concentration (BrEC) was 0.043+/-0.0197% and did not differ among the three caffeine treatments. As expected, ethanol reduced mean latency on the MSLT. The lowest caffeine dose reversed this effect and the highest dose increased mean latency (greater alertness) significantly beyond placebo levels. Ethanol also impaired psychomotor performance and memory. The 300-mg caffeine dose restored performance and memory measures to placebo levels. Although visual analog ratings of dizziness were increased by ethanol, they were not diminished by either caffeine dose. In conclusion, Low-dose caffeine prevented the sleepiness and performance impairment associated with a moderate dose of ethanol. Thus, caffeine, similar to other stimulants, can reverse the physiologically sedating effects of ethanol, although other negative effects remain.Coffee
New brain cells
The memory switch?
Growing new brain cells
Coffee and caffeine FAQ
Caffeine and noradrenaline
Coffee drinking helps prevent dementia
Is antioxidant-rich coffee a health drink?
Coffee, caffeine and Parkinson's disease
Caffeine, acetylcholine and the hippocampus
Caffeine/aspirin combo: effects on mood and performance
Refsand further reading
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family