Dietary cytidine (5')-diphosphocholine supplementation
protects against development of memory deficits in aging rats

Teather LA, Wurtman RJ.
Department of Brain and Cognitive Sciences,
Massachusetts Institute of Technology,
45 Carleton Street, E25-604,
Cambridge, MA, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27(4):711-7


The present study was designed to assess the effect of supplementation with dietary cytidine (5')-diphosphocholine (CDP-choline), a source of cytidine and choline, on memory in young and older rats. Although the hippocampal-dependent memory deficits in aged rats are well documented, cognitive functioning in early aging has not been as thoroughly evaluated. Female Sprague-Dawley rats (3 or 15 months of age) consumed either a control diet or a diet supplemented with CDP-choline (approximately 500 mg/kg/day) for 8 weeks, after which they were trained to perform spatial and cued versions of the Morris water maze. Compared with young rats, aged rats exhibited a selective deficit in spatial memory tasks that required rats to retain information for 24 h or longer. CDP-choline supplementation protected against the development of this deficit, but had no memory-enhancing effect in normal young rats. These findings suggest that early-aged rats display a selective impairment in hippocampal-dependent long-term memory, and that dietary CDP-choline supplementation can protect against this deficit.

New brain cells
The memory switch?
Cholinesterase inhibitors
Cytidine (5')-diphosphocholine
Anti-muscarinics/dumb-drug euphoria

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family