The matter of mind: molecular control of memory
by
Huang EP, Stevens CF.
Howard Hughes Medical Institute,
Salk Institute, La Jolla, CA 92037, USA.
Essays Biochem 1998;33:165-78


ABSTRACT

A widely accepted hypothesis suggests that changes in synaptic strength underlie the formation of memories in the brain. LTP is a mechanism of synaptic strengthening. Induction of LTP depends on NMDA receptor activation, and its expression depends in part on protein kinase activity. Studies of knock-out mice suggest that LTP is critical for hippocampus-based memory. Genetic studies in Drosophila implicate cAMP metabolism in classical conditioning, a form of unconscious memory. Consolidating memories for long-term retention depends on the cAMP-inducible transcription factor CREB.

CREB
New brain cells
The memory switch?
Dumb-drug euphoria
Growing new brain cells
The genetics of memory
Photographic memory in flies
Memory promoters and suppressors
The CREB pathway and memory enhancers
CREB and the discovery of cognitive enhancers



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