NMDA receptor modulation by D: -cycloserine promotes
episodic-like memory in mice

Zlomuzica A, De Souza Silva MA, Huston JP, Dere E.
Center for Biological and Medical Research,
Institute of Physiological Psychology,
Heinrich–Heine University of Düsseldorf,
40225, Düsseldorf, Germany,
Psychopharmacology (Berl). 2007 May 12;


RATIONALE: NMDA-R (N-methyl-D: -aspartate receptors) have been implicated in synaptic plasticity underlying one-trial learning of event-place associations. In rodents, episodic-like memory (ELM) of personally experienced events can be inferred from behavior that reflects the remembrance of the content (what kind of object was presented), place (where was this object placed), and temporal context (when was the object presented). We have previously shown that that D: -cycloserine (DCS), an NMDA-R agonist, ameliorates stress-induced deficits in ELM. OBJECTIVES: In this study, we used an experimental protocol designed to detect promnestic drug effects and investigated whether DCS, which is known to enhance learning and memory, can induce ELM under conditions where mice normally do not show ELM. RESULTS: Mice that have been treated i.p. with DCS (20 mg/kg) both remembered the temporal order in which two different objects had been encountered during two consecutive sample trials, as well as their spatial position during the sample trials. Most importantly, the test trial performance of these mice is compatible with ELM in terms of an integrated memory for unique experiences comprising "what", "where", and "when" information. In contrast, mice that have received either a saline injection or lower doses of DCS (0.2 and 2.0 mg/kg) did not show such an integrated ELM. CONCLUSIONS: To our knowledge, this is the first report showing that DCS can promote ELM in mice.

New brain cells
The memory switch?
Dumb-drug euphoria
Growing new brain cells
Acetyl-L-carnitine plus alpha-lipoic acid (Juvenon)

and further reading

Future Opioids
BLTC Research
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family