Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
Weinreb O, Mandel S, Amit T, Youdim MB.
Eve Topf and USA National Parkinson Foundation Centers of
Excellence for Neurodegenerative Diseases Research
and Department of Pharmacology,
Rappaport Family Research Institute,
Technion-Faculty of Medicine,
31096 Haifa, Israel.
J Nutr Biochem. 2004 Sep;15(9):506-16
ABSTRACTTea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, are examined and discussed in this review.
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