Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats
Suzuki S, Yamatoya H, Sakai M,
Kataoka A, Furushiro M, Kudo S.
Yakult Central Institute for Microbiological Research,
1796 Yaho, Kunitachi,
Tokyo 186-8650, Japan.
J Nutr 2001 Nov;131(11):2951-6
ABSTRACTSoybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean lecithin and L-serine by a transphosphatidylation reaction, and its effect on age-related memory impairment was evaluated in rats by the Morris water maze test. Continuous oral administration of SB-tPS (60 mg.kg(-1).d(-1) for 60 d) to male aged rats (24-25 mo) significantly improved performance in the water maze escape test (P < 0.01 vs. control aged rats) similar to bovine brain cortex-derived phosphatidylserine, which restores cognitive function in patients with senile dementia. SB-tPS also increased acetylcholine release and the Na(+), K(+)-ATPase activity of the synaptosomes prepared from these aged rats to the level in young rats. The nootropic actions of SB-tPS in the present study can be partly explained by the changes in these biochemical activities.Acetylcholine
New brain cells
The memory switch?
Growing new brain cells
Cholinergic precursor therapy
Phosphatidylserine: antidepressant and/or smart drug?
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