Effect of rubiscolin, a delta opioid peptide
derived from Rubisco, on memory consolidation
Yang S, Kawamura Y, Yoshikawa M.
Division of Food Bioscience and Biotechnology,
Graduate School of Agriculture,
Kyoto University, Uji,
611-0011, Kyoto, Japan.
Peptides. 2003 Feb;24(2):325-8
ABSTRACTRubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroventricular administration, and at 100mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the delta antagonist naltrindole, suggesting the involvement of the delta opioid receptor.Caffeine
New brain cells
The memory switch?
Growing new brain cells
Coffee, caffeine and Parkinson's disease
Refsand further reading
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family